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lizzyb

Registered: Jan 13, 2006
Posts: 1
Reply with quote  #1 

I am a frequent cystitis sufferer for many years and am now on permanent antibiotics. I am really keen to try Waterfall D-Mannose but am in the early stages of pregnancy. I have contacted the company directly and they think it is safe but there havn't been extensive enough trials to be 100% sure.

Has anybody else used this while pregnant?? I'd love to hear from you

Liz

atchan

Registered: Feb 8, 2006
Posts: 12
Reply with quote  #2 
Hi

I'm sorry to dig up an old thread, but I'm interested to hear if anyone's tried D-Mannose whilst being pregnant, since Lizzy's post (I noticed there's no responses)?

I've routinely relied on D-Mannose until I got pregnant, but stopped since. I know many website says they are safe for pregnant women, but I'd be most grateful if anyone can share their first hand experience for a bit of reassurance?

Many thanks, Atchan
DawnCOB

Moderator
Registered: Dec 2, 2003
Posts: 4,489
Reply with quote  #3 
Hi,

Taken from COB D-Mannose fact sheet . Hope this helps. best wishes Dawn

Safety

Natural D-Mannose is manufactured from birch/beech wood hydrolysate using a solvent-free separation process and is a white, crystalline powder. Natural D-Mannose is extremely safe, has no known side effects, and can be used by pregnant women and children. On the other hand, synthetically produced D-Mannose requires potentially harmful chemicals for its manufacture.

 

Contra-indications

D-Mannose could potentially bind to sperm, preventing implantation. Those trying to conceive should not supplement with D-mannose.


atchan

Registered: Feb 8, 2006
Posts: 12
Reply with quote  #4 
Dear Dawn

Thank you very much for the information. I will contact the manufacturer to see if mine's natural/synthetic.

Atchan
CazP

Registered: Nov 1, 2006
Posts: 122
Reply with quote  #5 

Hi... if you have been ok since stopping D-mannose, then it might be worth continuing without just to see how you go without?  wouldnt want to advise really, but last year I was in a similar position but taking another natural cure but decided to stop taking it just out of precaution because it hadnt really been tested, even though the concensus was that it "should" be ok.  Luckily my pregnancy went without a hitch and I only had a couple of short episodes of bladder discomfort - during one I took some amoxicillin out of precaution - you should always report a suspected UTI to your GP asap during pregnancy and you will find that they are usually pretty on the ball in treating it.  Your midwife will also be dipsticking your urine to see if there is infection (though remember dipstick tests arent that accurate in picking up infections).  Well I can only say how it was for me... only you will know and can decide whats right for you.   I hope your pregnancy goes smoothly, and wish you well.

dth1971

Registered: Oct 15, 2008
Posts: 3
Reply with quote  #6 
My wife and I found out in late May she was pregnent.

During the first doctor exam, we discovered she was infected with Klebsiella pneumonia.  This bacterium is normally asymptomatic.  (meaning shows no signs.)

We started several rounds of antibiotic treatments including Bactrim, and I.V. rounds of Invanz (class C drugs during pregnancy, meaning they should be used with caution.)

Unfortunately she has the multi-resistant strain variety of the bacterium.  There are no treatments left that will not harm our unborn child or my wife.

Fortunately she is in good health still.  The other good news is the bacteria will only become dangerous if it reaches her kidneys.  The doctor estimates a 1 in 5 chance of this happening.  He also said it is entirely possible that the body will flush (or shed) the bacteria itself from the bladder.   

As you can imagine, every day I have been looking up information on this bacteria, as well as potential treatments.

For two weeks, we have been trying 12->18 oz of concentrated 100% cranberry juice.  We have mixed this with D-Manoose and added 2000 mg of natural source vitamin C.  We have also upped her liquid intake in order to keep her kidney's flushed.

We are getting her tested again tomorrow.  We'll let you know how it goes.

Disclaimer: It is very important to note that I found this study:
Freinkel N, Lewis NJ, Akazawa S, Roth SI, Gorman L.
The honeybee syndrome: implications of the teratogenicity of mannose in rat-embryo culture.
N Engl J Med 1984;310:223-30.
It suggest Manoose can cause birth defects.

A number of sites claim it is safe.  We also did an ultra sound last week.  Our baby appears to be of perfect form, size, and weight.

We don't know if D-Mannose will work on Klebsiella.  But from everything I have been studying, it contains a similar binding mechanism to bladder walls as E.Coli.

We'll let you know the results.

dth1971

Registered: Oct 15, 2008
Posts: 3
Reply with quote  #7 
I almost can't believe it.

The dip-stick test came back NEGATIVE today.

It came up positive before!

They are running a bacterial culture to be sure.

dth1971

Registered: Oct 15, 2008
Posts: 3
Reply with quote  #8 
Culture and suspetability test back

Bacteria count is still greater than 100,000/mL :-(

Only tetracycline is left. 

D-Mannose didn't work.  Neither did cranberry juice.

The good news is she is she hasn't had any signs of kidney infection.

If anybody is reading this, I'm open to suggestions on how to keep her kidney's clean.

lema

Registered: July 9, 2011
Posts: 3
Reply with quote  #9 
Quote:
Originally Posted by dth1971
Culture and suspetability test back

Bacteria count is still greater than 100,000/mL :-(

Only tetracycline is left. 

D-Mannose didn't work.  Neither did cranberry juice.

The good news is she is she hasn't had any signs of kidney infection.

If anybody is reading this, I'm open to suggestions on how to keep her kidney's clean.

Hi, I just saw your post...I suppose now your baby is born and everything went fine.
i suffer from recurrent UTI and I am taking d-mannose for some months now, so far it has worked, but now I got another one..!
still waiting for the results of the culture, I tried with d-mannose but seems it doesn't work, so I took antibiotics.
Since I am trying to conceive, i was wondering if d-mannose is harmful..the past 2 days I took a lot of d-mannose, I wanted to ask you if you had any results about d-mannose being harmful during pregnancy or during ttc.
thank you
lema

Registered: July 9, 2011
Posts: 3
Reply with quote  #10 
hi, pleasE HELP!
I am currently ttc and taking d-mannose regularly (2 capsules/day) and so far it had worked fine, until I got another Uti and so I increased the dose for 1 and 1/2 day  (took 3 capsules/2hours), until I found your posts -and others- on the internet about d-mannose causing teratogenecity.
I am really concerned, don't know if I'm pregnant yet, but still very concerned.
Of course as soon as I read these reviews and the article itself, I stopped taking it.
And I was wondering: did everything go fine with you wife's pregnancy?? At the end d-mannose was ok to use during pregnancy??
thank you

DawnCOB

Moderator
Registered: Dec 2, 2003
Posts: 4,489
Reply with quote  #11 
Hi,

Here is a following link that may be of interest ....

http://pedsurgerycenter.com/patient-education/?id=225997&lang=English&db=hlt&ebscoType=static&widgetTitle=Otolaryngology+(Ear%2C+Nose%2C+%26+Throat)

Safety Issues

As a sugar widely present in foods, mannose is assumed to be safe. However, the maximum safe dosage has not been established in healthy adults, nor in pregnant or nursing women or young children. Very weak evidence from test tube studies hints that consumption of gigantic amounts of mannose by pregnant women could conceivably increase risk of birth defects in their offspring. 6-8
 
If you have any concerns you should speak to your GP.

best wishes
Dawn

lema

Registered: July 9, 2011
Posts: 3
Reply with quote  #12 
Hi,
thank you so much for your answer!
My first question is: what is a "gigantic" amount??
What I took is considered "gigantic"?
I took around 13 capsules of 500 mg the first day of acute uti and around 22 the second day.
And then I stopped and took antibiotics. Consider I was drinking A LOT of water and trying to urinate every half or one hour in order to have a lot of urine to flush away the bacterias.
I had asked my GP about d-mannose before starting taking it, but he had not given any importance to this, since I told him it was a natural sugar.
And my other question is: the problem consists if taking d-mannose in early pregnancy?
What exactly is considered EARLY pregnancy? I mean, the first two days after intercourse, when the embryo is 1 or 2 days old, (of course IF the egg has been inseminated and so we have pregnancy), are considered early pregnancy, or is it TOO TOO early??
I've read the article about embryo rats and it talks about infusing d-mannose in pregnant rats at days 9.5-10 of gestation:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC425550/

thank you 

DawnCOB

Moderator
Registered: Dec 2, 2003
Posts: 4,489
Reply with quote  #13 
Hello,

I would contact the following people they may be able to help you with advice on dosages etc.

http://www.sweet-cures.com/contact_sweet_cures.htm

best wishes
Dawn
Lavinia

Registered: May 21, 2013
Posts: 1
Reply with quote  #14 
I know this thread is old, but as it still comes up on google searches - and a couple of people in it have quoted a rat embryo study suggesting d-mannose is unsafe in pregnancy -I thought I would share this reassuring snip of the same study's abstract:

"The relevance of our present findings should not rest on the possible role of mannose as an important teratogen in man. Excessive exposure to mannose during pregnancy via dietary intake seems unlikely since mannose is absorbed poorly from the gastrointestinal tract and intestinal hydrolysis of mannosidic linkages may be minimal."

Sounds safe to me. They directly infused test tube embryos' cultures with d-mannose, so the study wasn't using digestive mechanisms of pregnant rats to test d-mannose effects; it was soaking embryos in it.

Having done this reading I decided to go ahead and take it. I have been using it for two days now (10 days from my due date) and it has been miraculously effective for me. The dangers of uti's in pregnancy scare me a heck of a lot more
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